简介 | 1 Schisandrin C could be used as a natural anti-neuroinflammatory agent, inducing phase II detoxifying antioxidant enzymes via cAMP PKA CREB and Nrf-2 signaling 2 Schisandrin C induced G1 arrest was correlated with down-regulation of cyclin D1, cyclin E, cyclin-dependent kinase (Cdk) 4 and E2Fs expression, inhibition of phosphorylation of retinoblastoma protein (pRB), and up-regulation of the Cdk inhibitor p21(WAF1 CIP1) 3 Schisandrin C induced apoptosis was associated with down-regulation of expression of the anti-apoptotic proteins Bcl-2 and Bcl-xL, proteolytic activation of caspase-3 and -9, and a concomitant degradation of poly(ADP-ribose) polymerase (PARP) 4 Schisandrin C reduces liver impairment in acute and chronic liver diseases
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